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Hassan Arbab

Senior Research Scientist/Engineer

Email

mharbab@apl.washington.edu

Phone

206-685-8225

Research Interests

Terahertz spectroscopy, Ultrafast photonics and femtosecond optics, Wavelet methods, Biomedical optics

Education

B.S. Electrical Engineering, Shahid Beheshti University, 2004

M.S. Electrical Engineering, University of Washington, 2008

Ph.D. (dual) Electrical Engineering and Nanotechnology, University of Washington, 2012

Publications

2000-present and while at APL-UW

Terahertz spectroscopy for the assessment of burn injuries in vivo

Arbab, M.H., D.P. Winebrenner, T.C. Dickey, A. Chen, M.B. Klein, and P.D. Mourad, "Terahertz spectroscopy for the assessment of burn injuries in vivo," J. Biomed. Opt., 18, 077004, doi:10.1117/1.JBO.18.7.077004, 2013.

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1 Jul 2013

A diagnosis criterion is proposed for noninvasive grading of burn injuries using terahertz radiation. Experimental results are presented from in vivo terahertz time-domain spectroscopy of second- and third-degree wounds, which are obtained in a 72-hour animal study. During this period, the change in the spectroscopic response of the burned tissue is studied. It is shown that terahertz waves are sensitive not only to the postburn formation of interstitial edema, but also to the density of skin structures derived from image processing analysis of histological sections. Based on these preliminary results, it is suggested that the combination of these two effects, as probed by terahertz spectroscopy of the tissue, may ultimately be used to differentiate partial-thickness burns that will naturally heal from those that will require surgical intervention.

A noninvasive terahertz assessment of 2nd and 3rd degree burn wounds

Arbab, M.H., D.P. Winebrenner, T.C. Dickey, M.B. Klein, A. Chen, and P.D. Mourad, "A noninvasive terahertz assessment of 2nd and 3rd degree burn wounds," In Proceedings, CLEO 2012: Conference on Lasers and Electro-Optics, San Jose, CA, paper CTu3B.3 (Optical Society of America, 2012).

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6 May 2012

We demonstrate the application of THz-TDS in characterizing the severity of burn injuries in a live animal model. 2nd and 3rd degree burns were studied immediately and 72 hours post-burn. A new diagnosis criterion was verified against histopathology.

Terahertz reflectometry of burn wounds in a rat model

Arbab, M.H., T.C. Dickey, D.P. Winebrenner, A. Chen, M.B. Klein, and P.D. Mourad, "Terahertz reflectometry of burn wounds in a rat model," Biomed. Opt. Express, 2, 2339-2347, doi:10.1364/BOE.2.002339, 2011.

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21 Jul 2011

We present sub-millimeter wave reflectometry of an experimental rat skin burn model obtained by the Terahertz Time-Domain Spectroscopy (THz-TDS) technique. Full thickness burns, as confirmed by histology, were created on rats (n = 4) euthanized immediately prior to the experiments. Statistical analysis shows that the burned tissue exhibits higher reflectivity compared to normal skin over a frequency range between 0.5 and 0.7 THz (p < 0.05), likely due to post-burn formation of interstitial edema. Furthermore, we demonstrate that a double Debye dielectric relaxation model can be used to explain the terahertz response of both normal and less severely burned rat skin. Finally, our data suggest that the degree of conformation between the experimental burn measurements and the model for normal skin can potentially be used to infer the extent of burn severity.

More Publications

Characterization of burn injuries using terahertz time-domain spectroscopy

Arbab, M.H., T.C. Dickey, D.P. Winebrenner, A. Chen, and P.D. Mourad, "Characterization of burn injuries using terahertz time-domain spectroscopy," Proc. SPIE, 7890, 78900Q, doi:10.1117/12.876229, 2011.

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10 Feb 2011

The accuracy rates of the clinical assessment techniques used in grading burn injuries remain significantly low for partial thickness burns. In this paper, we present experimental results from terahertz characterization of 2nd and 3rd degree burn wounds induced on a rat model. Reflection measurements were obtained from the surface of both burned and normal skin using pulsed terahertz spectroscopy. Signal processing techniques are described for interpretation of the acquired terahertz waveform and differentiation of burn wounds. Furthermore, the progression of burn injuries is shown by comparison between acute characterization and 72-hours survival studies. While the water content of healthy and desiccated skin has been considered as a source of terahertz signal contrast, it is demonstrated that other biological effects such as formation of post-burn interstitial edema as well as the density of the discrete scattering structures in the skin (such as hair follicles, sweat glands, etc.) play a significant role in the terahertz response of the burn wounds.

Retrieval of terahertz spectroscopic signatures in the presence of rough surface scattering using wavelet methods

Arbab, M.H., D.P. Winebrenner, E.I. Thorsos, and A. Chen, "Retrieval of terahertz spectroscopic signatures in the presence of rough surface scattering using wavelet methods," Appl. Phys. Lett., 97, doi:10.1063/1.3507384, 2010.

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1 Nov 2010

Scattering of terahertz waves by surface roughness can obscure spectral signatures of chemicals at these frequencies. We demonstrate this effect using controlled levels of surface scattering on alpha-lactose monohydrate pellets. Furthermore, we show an implementation of wavelet methods that can retrieve terahertz spectral information from rough surface targets. We use a multiresolution analysis of the rough-surface-scattered signal utilizing the maximal overlap discrete wavelet transform (MODWT) to extract the resonant signature of lactose. We present a periodic extension technique to circumvent the circular boundary conditions of MODWT, which can be robustly used in an automated terahertz stand-off detection device.

Application of wavelet transforms in terahertz spectroscopy of rough surface targets

Arbab, M.H., D.P. Winebrenner, E.I. Thorsos, and A. Chen, "Application of wavelet transforms in terahertz spectroscopy of rough surface targets," Proc. of SPIE, 7601, Terahertz Technology and Applications III, L.P. Sadwick and C.M.M. O'Sullivan, eds., doi:10.1117/12.845944, 2010.

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18 Feb 2010

Previously, it has been shown that scattering of terahertz waves by surface roughness of a target can alter the terahertz absorption spectrum and thus obscure the detection of some chemicals in both transmission and reflection geometries. In this paper it is demonstrated that by employing Maximal Overlap Discrete Wavelet Transform (MODWT) coefficients, wavelet-based methods can be used to retrieve spectroscopic information from a broadband terahertz signal reflected from a rough surface target. It is concluded that while the commonly used direct frequency domain deconvolution method fails to accurately characterize and detect the resonance in the dielectric constant of rough surface lactose pellets, wavelet techniques were able to successfully identify such features.

Measurement and application of incoherent terahertz scattering using time-domain spectroscopy

Arbab, M.H., D.P. Winebrenner, A. Chen, D. Wang, E.I. Thorsos, and L.M. Zurk, "Measurement and application of incoherent terahertz scattering using time-domain spectroscopy," Proceedings, 33rd International Conference on Infrared and Millimeter Waves and 16th International Conference on Terahertz Electronics, 15-29 September, Pasadena, CA (IEEE, 2008).

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15 Sep 2008

Measurement of incoherent rough surface scattering powers in terahertz frequency regime by means of time-domain spectroscopy has been for the first time demonstrated. Furthermore, applications of such incoherent measurements in spectroscopy and detection of chemicals are presented.

Effect of surface scattering on terahertz time domain spectroscopy of chemicals

Arbab, M.H., A. Chen, E.I. Thorsos, D.P. Winebrenner and L.M. Zurk, "Effect of surface scattering on terahertz time domain spectroscopy of chemicals," Proc. SPIE, 6893, Terahertz Technology and Applications, K.J. Linden and L.P. Sadwick, eds., doi:10.1117/12.769015, 2008.

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14 Feb 2008

The existence of unique absorption spectrum patterns for many chemicals at terahertz frequencies has opened an exciting avenue in non-contact safe detection of such materials by terahertz spectroscopy. However, scattering of THz waves, which have wavelengths on the order of material grain sizes, by surface roughness challenges the sensitivity of this detection scheme in practice. In this work, we present terahertz time domain spectroscopy results for materials with rough surfaces. Both reflection from and transmission through lactose, which has sharp absorption peaks in the terahertz regime, are studied and the effect of increasing scattering through controlled surface roughness is investigated. Such electromagnetic scattering can alter the terahertz absorption spectrum and thus obscure the detection of chemicals. Furthermore we examine electro-optic detection of terahertz signals reflected from randomly rough targets with a theoretical electromagnetic system perspective and provide a method to retrieve coherent reflection responses from rough surface targets.

Inventions

Methods and systems for assessing a burn injury

The present invention provides methods, software, and systems for assessing a burn injury.

Patent Number: 9,295,402

Hassan Arbab, Antao Chen, Dale Winebrenner, Trevor Dickey, Pierre Mourad, Matthew Klein

Patent

29 Mar 2016

Terahertz spectroscopy of rough surface targets

Patent Number: 9,261,456

Hassan Arbab, Antao Chen, Eric Thorsos, Dale Winebrenner

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Patent

16 Feb 2016

A method and system for analyzing noisy terahertz spectroscopy data transforms the measured time-dependent data into frequency space, for example, using a discrete Fourier transform, and then transforms the frequency spectrum into wavelet frequency space. The twice-transformed data is analyzed to identify spectroscopic features of the signal, for example, to identify a resonance frequency. The method may be used, for example, in a stand-off detector to identify particular chemicals in a target.

Method for Characterization of Superficial Wounds

Record of Invention Number: 45573

Hassan Arbab, Antao Chen, Dale Winebrenner, Trevor Dickey, Pierre Mourad, Matthew Klein

Disclosure

1 Apr 2011

More Inventions

Retrieval of Terahertz Spectroscopic Information in the Presence of the Rough Surface Scattering Effects

Record of Invention Number: 8575D

Hassan Arbab, Antao Chen, Eric Thorsos, Dale Winebrenner

Disclosure

20 Jan 2010

Acoustics Air-Sea Interaction & Remote Sensing Center for Environmental & Information Systems Center for Industrial & Medical Ultrasound Electronic & Photonic Systems Ocean Engineering Ocean Physics Polar Science Center
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